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Pathology

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GIT

Question
24 out of 53
 

Which not true regarding coeliac disease - (PGI June 2009)



A Total and sub-total villous atrophy

B Increased chance of lymphoma

C Anti-gliadin antibody persists even after gluten free diet

D Increased disacharidases

Ans. D i.e., ↑ disacharidases [Ref: Robbin's : Page-295]

a. In coeliac sprue:

i. Total or subtotal villous atrophy

ii. Increased chance of lymphoma

iii. Association with dermatitis herpetiformis

iv. Antigliadin antibody

v. Secondary lactase deficiency

vi. No mucosal atrophy

vii. Lymphocytes in lamina propria

b. Following information have been added to 8th edn. of Robbins

i. The most sensitive non-invasive serological tests are the presence of IgA antibodies to tissue transglutaminase

or IgA/IgG antibodies to deaminated gliadin.

ii. Anti-endomysial antibodies are highly specific but less sensitive.

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