Which of the following in its parenteral form is lifesaving in severe status asthmaticus and acts, at least in part, by inhibiting phospholipase A2? (LQ)
a. Parenteral corticosteroids such as Prednisolone are lifesaving in status asthmaticus. Anti-inflammatory action of coricosteriods is due to decreased recruitment of inflammatory cells as well as decreased production of PGs and LTs.
b. Arachidonic acid (AA) is released from the membrane phospholipids with the help of enzyme phospholipase C that is inhibited by corticosteroids. AA is converted to PG and TX by cyclooxygenase and to LT with the help of enzyme 5-lipooxygenase (5 LOX) .