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Physiology

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Nerve Muscle Physiology

Question
2 out of 19
 

Which of the following is NOT a Sarcolemmal protein? (AIPG 2008)



A Perlecan
B Dystrophin

C Dystroglycan
D Sarcoglycan

Ans. A Perlecan

a. A large protein called dystrophin (MW-427,000)forms a rod that connects the thin actin filaments to the transmembrane protein dystroglycan in the sarcolemma. This dystrophin-glycoprotein complex adds strength to the muscle by providing a scaffolding for the fibrils and connecting them to the extracellular environment.

b. Perlecan is a large multi-domain proteoglycan that binds to and cross-links many extracellular matrix (ECM)components and cell- surface molecules.

c. Perlecan is synthesized by both vascular endothelial and smooth muscle cells and deposited in the extracellular matrix.

d. Perlecan is a key component of the vascular extracellular matrix, here it interacts with a variety of other matrix components and helps to maintain the endothelial barrier function.

e. Perlecan is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis.

f. Perlecan can also promotes growth factor (e. g. ,FGF2)activity and thus stimulate endothelial growth and re-generation.

Nerve Muscle Physiology Flashcard List

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