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Medicine

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Endocrine

Question
13 out of 28
 

Which of the following is a amylin agonist drug? PNQ



A Glargine
B Aspart

C Pramlintide
D None of the above

Ans. C

Pramlintide

Recent Advances (Ref. Hari-18th ed. Pg-2997)

New concepts and new drugs in diabetes. (PNQ)

1). Incretin effect (Physiology) (PNQ)

a). Normally when anybody eats food it causes increased insulin secretion.

b). In a new study it is seen that normal people who take oral glucose tend to have higher serum insulin level as compared to those normal people to whom glucose was given intravenous although blood sugar was same in both the groups of people. It is because oral glucose causes release of some polypeptide from the intestine which raise serum insulin level (insulinotropic polypeptide).

c). These polypeptide include GLP- 1, GIP

d). These two polypeptide are degraded by DPP - IV Enzyme

Pharmacology: (PNQ)

a. New anti-diabetic drugs which raised GLP -1 and GIP

i. Exenatide (Injection)

ii. Liraglutide (Injection)

b. New anti-diabetic drugs which raised GLP1 and GIP level by inhibiting DPP – IV (DPP – IV inhibitors)(PNQ)

i. Sitagliptin (Oral)

ii. Vildagliptin (Oral)

iii. Saxagliptin

iv. Ritagliaptin

v. Alogliaptin

2). Amylin effect (Physiology): (PNQ)

a. Normally when we eat food, intestine secretes amylin

b. Amylin reduces glucagon secretion and slows down the gastric emptying.

Pharmacology: (PNQ)

New anti-diabetic drugs which increases amylin secretion (Amylin agonist)

Pramlintide (Injection)

Endocrine Flashcard List

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