14 out of 42
Which of the following is false regarding spectrin:
|A||Protein in nature|
|B||Functions are similar to ankyrin|
|C||Deficiency leads to hereditary spherocytosis|
|D||It is responsible for primary structure of cell wall|
Ans. D It is responsible for primary structure of cell wall
- The molecular defect in hereditary spherocytosis involves the proteins of the underlying cytoskeleton Q.
- Nearly 100% patients have a considerable deficiency of SPECTRIN Q.
- Spectrin is the major skeletal protein of filamentous nature.
- It consists of two polypeptide chains a and which are intertwined.
- It is connected laterally via two additional proteins namely protein 4.1 and actin.
- This two dimensional cable meshwork is tethered (bounded) to the cell membrane by another protein called ANKYRIN which forms a bridge between spectrin and cell membrane protein 3.
- About 50% of patients have a defect in ankyrin Q.