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Physiology

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Blood

Question
14 out of 42
 

Which of the following is false regarding spectrin:



A Protein in nature

B Functions are similar to ankyrin

C Deficiency leads to hereditary spherocytosis

D It is responsible for primary structure of cell wall

Ans. D It is responsible for primary structure of cell wall
  1. The molecular defect in hereditary spherocytosis involves the proteins of the underlying cytoskeleton Q.
  2. Nearly 100% patients have a considerable deficiency of SPECTRIN Q.
  3. Spectrin is the major skeletal protein of filamentous nature.
  4. It consists of two polypeptide chains a and which are intertwined.
  5. It is connected laterally via two additional proteins namely protein 4.1 and actin.
  6. This two dimensional cable meshwork is tethered (bounded) to the cell membrane by another protein called ANKYRIN which forms a bridge between spectrin and cell membrane protein 3.
  7. About 50% of patients have a defect in ankyrin Q.

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