Which of the following is the drug of choice for syndrome of inappropriate secretion of antidiuretic hormone (SIADH)?
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is due to excessive secretion of Arginine vasopressin (AVP) : Drugs that block the effect of Arginine vasopressin (AVP) on the renal tubule are sometimes useful. Demeclocycline is the most potent inhibitor of AVP action available for chronic administration.
Remember: Tetracycline’s (Demeclocycline) causes Diabetes Insipidus. So the treatment of SIADH is by inducing DI .