Loading....
Coupon Accepted Successfully!

Pharmacology

Open Flashcards

Antimicrobial Part-2

Question
16 out of 75
 

Which of the following is most common adverse effect of zalcitabine: (AIIMS Nov 2011)



A Pancreatitis

B Bone marrow suppression

C Stomatitis

D Peripheral neuropathy transaminase levels

Ans. D Peripheral neuropathy transaminase levels.

a. Zalcitabine is a cytosine analogue reverse transcriptase inhibitor.

b. The major adverse events of zalcitabine administration are peripheral neuropathy, stomatitis, rash and pancreatitis.

c. Zalcitabine-associated peripheral neuropathy is dose related and is more common with pre-existing neuropathy and advanced disease. Alcohol consumption, diabetes and low vitamin B12 levels also are associated with an increased risk of zalcitabine-associated neuropathy. Severe neuropathy.

d. Symptoms include numbness, burning, and tingling of the feet. Stomatitis with ulceration of buccal mucosa, soft palate, tongue and pharynx occurs in 3% of patients and may resolve with continued therapy.

e. Pancreatitis is a rare complication of zalcitabine therapy. Mild and self-limited rash is common but rarely necessitates discontinuation of therapy. Other toxicities include arthralgias, myalgias, and elevated transaminase levels.

Antimicrobial Part-2 Flashcard List

75 flashcards
1)
2)
3)
4)
5)
6)
7)
8)
9)
10)
11)
12)
13)
14)
15)
16)
17)
18)
19)
20)
21)
22)
23)
24)
25)
26)
27)
28)
29)
30)
31)
32)
33)
34)
35)
36)
37)
38)
39)
40)
41)
42)
43)
44)
45)
46)
47)
48)
49)
50)
51)
52)
53)
54)
55)
56)
57)
58)
59)
60)
61)
62)
63)
64)
65)
66)
67)
68)
69)
70)
71)
72)
73)
74)
75)