Which of the following is calculated as the ratio of the area under the curve (AUC). obtained by oral administration Vs the AUC for intravenous administration of the same drug? (LQ)
|D||Elimination rate constant|
The AUC of a drug given intravenously (which, by definition, is associated with a bioavailability of 1.0, or 100%) is prerequisite for knowing the bioavailability of the same drug given by any other route; bioavailability is calculated as the ratio of AUC for any non-IV route and the AUCIV.