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Medicine

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Rheumatology

Question
3 out of 30
 

Which of the following is the initial site of disease inRA? (AI 2000)



A Cartilage
B Synovium

C Bone
D Tendon

Ans. B Synovium. Initial site of disease is synovial membrane

RA is a chronic autoimmune multisystem disease having inflammatory arthritis and systemic manifestation.

Pathogenesis –

A. Women (30 to 50 years) are more commonly affected

B. HLA-DR 4 Q is a risk factor for RA.

C. Initial site of disease is synovial membrane

Initiation phase – It is due to non – specific inflammation

Amplification phase – Due to T cell activation

Chronic inflammatory phase – Due to cytokines IL – 1, TNF- alpha (AIPG 2009) and IL – 6

Rheumatology Flashcard List

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