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Biochemistry

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Lipid

Question
22 out of 63
 

Which of the following is an activator of LCAT



A Apo B 100

B Apo B 48

C Apo E

D Apo Al

Ans. D Apo-A-I

a. APO-AI Synthesized in Liver and intestine

i. Most common protein of HDL 70%-80% protein of HDL

ii. Is a LCAT Activator

iii. Inversely related to risk for CHD

b. APO-B48major constituents of chylomicron synthesized in intestine

c. APO-B100 — major constituent of LDL 90% protein of LDL

1. 60% proteins of IDL and

30% proteins of VLDL

  1. APO — E synthesized mainly in liver, but also in macrophages, neuron cells and glial cells; found in chylomicron VLDL, IDL, HDL
  2. APO C-II activator of Lipoprotein lipase
  3. APO C-III Inhibitor of Lipoprotein Lipase Harrison 16th inhibit Lipoprotein binding to Receptors

APO — A-Il HDL, chylomicrons Inhibitor of LCAT and APo-A-I

APO — B — 100 is one of the longest single polypeptide chains known, having 4536 amino acid; APO — B —48 is formed from the same mRNA as Apo — B —100, but in the intestine, as stop codon that is not present in genomic DNA is introduced by an RNA Editing mechanism that stops translation at amioacid residue 2153 to liberate APO-B-48.

Lipid Flashcard List

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