Which of the following is not compatible with a diagnosis of chronic myelomonocytic leukemia? (AIIMS Nov 2010)
|A||Peripheral blood monocytosis more than 1 x 109/L|
|B||Absence of Philadelphia chromosome|
|C||More than 20% blasts in blood or bone marrow|
|D||Absent or minimal dysplasia in myeloid lieages.|
More than 20% blasts in blood or bone marrow
Diagnostic Criteria for Chronic Myelomonocytic Leukemia according to WHO
1. It is a chronic disorder (a variant of C.M.L)
2. Middle aged and elderly males are usually affected
3. Persistent peripheral blood monocytosis is >1 x 109/L.
4. Absence of Philadelphia chromosome or BCR/ABL rearrangement
5. Blasts are less than 20% in peripheral blood or bone marrow.
6. Dysplasia in one or more myeloid lineages, or in the absence of dysplasia, CMML can be diagnosed, if all other criteria are met together with either of the following
7. Presence of clonal cytogenetic abnormality
8. Monocytosis has been persistent for at least 3 months and all other causes of monocytosis have been excluded