Which of the following is not a 'heterophile reaction':
|A||Weil Felix test|
|B||Paul Bunnell test|
|D||Cold agglutinin test|
a. Frie’s test is used in the diagnosis of LGV. Antigen made from sterile pus aspirated from previously unruptured LGV abscesses, produces a reaction in patients with lymphogranuloma inguinale when injected intradermally.
Similar antigens on dissimilar organisms are called heterophile antigens
b. Closely related antigens can occur on a wide variety of organisms.
c. Antibodies reacting with such antigens are called heterophile antibodies. Serologic tests employing such antigens are called heterophile tests.
Heterophile antigen tests: Paul bunnel test, Cold agglutinin test, Agglutination of streptococcus MG, Weil Felix reaction.
- Sheep RBCs agglutinate in the presence of heterophile antibodies and are the basis for the Paul-Bunnell test in Infectious mononucleosus.
- Agglutination of horse RBCs on exposure to heterophile antibodies is the basis of the Monospot test in Infectious mononucleosus.
- Patients suffering from some rickettsial diseases develop agglutinins against certain nonmotile strains of Proteus. This is the basis of Weil Felix test.
- Patients suffering from some Mycoplasma pneumoniae infection develop agglutinins against human blood group O RBC’s. This is the basis of cold agglutination test.
- Patients suffering from some Mycoplasma pneumoniae infection develop agglutinins against Group F Streptococcus. This is the basis of Streptococcus MG test test.