Physiological Changes in Pregnancy
Which of the following is present normally in the urine of a pregnant women in the third trimester and lactation? (AIIMS Nov. 2010)
a. Glucosuria during pregnancy is not necessarily abnormal.
b. The appreciable increase in glomerular filtration, together with impaired tubular reabsorptive capacity for filtered glucose, accounts in most cases for glucosuria.
c. For these reasons alone, about one sixth of all pregnant women should spill glucose in the urine.
d. Even though glucosuria is common during pregnancy, the possibility of diabetes mellitus should not be
e. Ignored when it is identified.
f. But the question asked here is specific for the period of end pregnancy and lactation and here Lactose excretion is more specific as breast feeding gets established in this time.
g. The mechanism by which lactose appears in the plasma and urine of pregnant and lactating women is not well understood. One possible mechanism is transcellular or paracellular leaking of lactose and sodium from milk into extracellular fluid as observed in humans and even cattle during pregnancy
h. Elevation in human plasma lactose for up to 3 months postpartum provides additional evidence that either paracellular leaking or some other mechanism exists for the transport of lactose into plasma.