Which of the following is not seen in a chronic case of Sickle cell anemia: (DNB Dec 2010)
1. Anemia (Hb 6 –8 gm/dl), reticulocytosis (10 –20%), jaundice, painful swelling of hands and feet.
2. Splenomegaly is not a feature (autosplenectomy occurs Q).
3. Chronic ill – health, renal failure, bone pain necrosis, infections, leg ulcers can result, Pulmonary arterial hypertension
Extra Edge: “Sickle cell anemia is characterized by Hyposplenism due to Autosplenectomy”