Which of the following is not found in cryop-recipitate:
a. Cryoprecipitate is prepared from plasma and contains fibrinogen, von Willebrand factor, factor VIII, factor XIII and fibronectin. Cryoprecipitate is the only adequate fibrinogen concentrate available for intravenous use.
b. Cryoprecipitate is available in pre-pooled concentrates of six units. Each unit from a separate donor is suspended in 15 mL plasma prior to pooling. For use in small children, up to 4 single units can be ordered. Each unit provides about 350 mg of fibrinogen.( 75% recovery in blooD.
Indications for Cryoprecipitate
a. Bleeding or immediately prior to an invasive procedure in patients with significant hypofibrinogenemia (<100 mg/dL).
b. Cryoprecipitate should not be used for patients with von Willebrand disease or Hemophilia A (Factor VIII deficiency) unless they do not (or are not known to) respond to DDAVP
c. Recombinant and/or virally inactivated preparations are not available.
d. It is not usually given for Factor XIII deficiency, as there are virus-inactivated concentrates of this protein available.
e. Cryoprecipitate is sometimes useful if platelet dysfunction associated with renal failure does not respond to dialysis or DDAVP.