Autonomic Nervous Systems
Which of the following is an enzyme inducer?
Many drugs, insecticides and carcinogens interact with DNA and increase the synthesis of microsomal enzyme proteins, especially cytochrome P-450 and glucuronyl transferase. As a result of this, the rate of metabolism of inducing drug itself and / or other drugs is increased. Different 'inducers' are relatively selective for certain cytochrome P-450 families:
- Anticonvulsants such as phenobarbitone, rifampin, macrolide antibiotics, and glucocorticoids induce CYP3A isoenzymes;
- Phenobarbitone also induces CYP2B1 and rifampin also induces CYP2D6
- Isoniazid and chronic alcohol consumption induces CYP2E1;
- Other important enzyme inducers are chloral hydrate, phenylbutazone, griseofulvin and DOT.