Which of the following is the most likely adverse response to occur as a result of the vincristine? (LQ)
a. Vincristine is one of relatively few cytotoxic anticancer drugs that does not cause bone marrow suppression (and all the potential consequences of that) as its main toxicity. Rather, it causes neuropathies involving both sensory and motor nerves.
b. Paresthesias are a common example of the former (hearing loss can also occur); muscle weakness and obtunded reflexes are examples of the latter.
(Mnemonic: Vincristine: CNS side effect; Vinblastine: Blood side effect)