Gram Negative Spiral
Which of the following is an important distinguishing characteristic of H. pylori as compared to Campylobacter species?
a. Both Campylobacter species and H. pylori have a curved shape, are oxidase and catalase positive, with polar flagellum. Urease production is the distinguishing factor of H.
b. pylori, and it is the basis of the rapid urease breath test that diagnoses H. pylori infection.
a. The most common bacterial infection of man.
b. Spiral, curved or U/ S shaped, Gram negative
c. Gastric group-H. pylori and H. heilmanii: human gastric disease
d. Enterohepatic group-H. cinaedi and H. fenneliae: enteritis and proctocolitis
e. Motile by sheathed lophotrichous (~7) flagella.
f. Microaerophilic and capnophilic
g. Non fermenter. Oxidase and catalase positive.
h. Urease strongly positive (max. urease production ).
i. Unique sole niche –surface of Gastric type of epithelial cells in and beneath the layer of mucus attached to the surface of gastric epithelium (M/c site-antrum). Does not appear to invade tissues.
j. Feco-oral or oro-oral (gastro-esophageal reflux) spread
k. More than 50% of world population is colonized. Upto 80% colonization in developing countries.
l. Colonization leads to chronic active gastritis-antral –Type B / pangastritis.
m. Warren and Marshall got Nobel Prize in 2005 for discovering the association with PU.
n. 80% of Duodenal ulcers and 60% of gastric ulcers attributable.
o. Class I human carcinogen-associated with MALTomas and gastric adenocarcinoma.