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Medicine

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Neurology

Question
5 out of 5
 

Which of the following is not a channelopathy



A Periodic paralysis
B Tay Sachs disease

C Cystic fibrosis
D Liddle syndrome

Ans. B

Tay Sachs disease

Other types of Channelopathies

Condition

Channel type

Alternating hemiplegia of childhood

Na+/K+-ATPase

Bartter syndrome, Liddle

various by type

Cystic fibrosis

Chloride channel

Episodic Ataxia

Voltage-gated potassium channel

Generalized epilepsy with febrile seizures plus

Voltage-gated sodium channel

Familial hemiplegic migraine

various

Hyperkalemic periodic paralysis

Voltage-gated sodium channel

Hypokalemic periodic paralysis

Voltage-gated sodium channel

or
voltage-dependent calcium channel (calciumopathy)

Long QT syndrome

main type Romano-Ward syndrome

various, by type

Malignant hyperthermia

Ligand-gated calcium channel

Myasthenia Gravis

Ligand-gated sodium channel

Myotonia congenita

Voltage-dependent chloride channel

Neuromyotonia

Voltage-gated potassium channel

Paramyotonia congenita

(a periodic paralysis)

Voltage-gated sodium channel

Retinitis pigmentosa

(some forms)

Ligand-gated non-specific ion channels

Short QT syndrome

various potassium channels suspected

Seizure

Voltage-dependent potassium channel

Extra Edge: Channelopathy is not feature of TB, spinocerebellar ataxia and Tay Sach’s disease.