Which of the following is appropriate and generally regarded as most effective for relieving and preventing ischemic episodes in patients with variant angina?
a. In variant angina. The etiology involves coronary vasospasm, and that can be blocked well with a calcium channel blocker: diltiazem, verapamil.
b. The CCBs block coronary vascular smooth muscle influx of calcium, which is a critical process in triggering spasm.
c. Nitroglycerin seems to be marginally effective in terms of long-term symptom relief, although it may be the only rapidly acting drug that will be efficacious for acute angina and self-medication.
d. Aspirin, through its antiplatelet aggregatory effects, would be beneficial, prophylactically, if coronary thrombosis were part of the etiology of variant angina; but it isn’t.