Which of the following is false regarding acyclovir:
|A||It inhibits DNA synthesis and viral replication|
|B||It is effective against influenza|
|C||It has low toxicity for host cells|
|D||Renal impairment necessitates dose reduction|
a. ACYCLOVIR is converted to acyclovir monophosphate, which is a nucleotide, by the viral thymidine kinases of herpes simplex virus (HSV) and varicella-zoster virus (VZV).
b. Acyclovir monophosphate is converted to the diphosphate by cellular guanylate kinase and to the triphosphate by a number of other cellular enzymes. Acyclovir triphosphate interferes with herpes simplex virus and varicella zoster virus DNA polymerase enzymes and inhibits viral DNA replication.
c. Drugs effective against influenza are: ostemvarir, zanamivir, amantadine and rimantadine. First two are effective in treatment, while last two are effective in prophylaxis.