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6 out of 6

Which of the following is not a cyclin dependent kinase (CDK) inhibitor:(AIPG 2011)

A p21
B p27
C p53
D p57

Ans. C p53

a. Cyclin and cyclin - Dependent Kinases in regulation of cell cycle.

i. Cyclin D/CDK4, cyclin D/CDK6 and cyclin E/CDK2 regulate G1- S transition by phosphorylation of the Rb protein

ii. Cyclin B/CDK 1 help in G2 - M transition

b. CDK Inhibitors ­

i. INK4 inhibitors composed of p16, p15, p19 and p18 act on cyclin D/CDK 4 and cyclin D/CDK 6

ii. p21, p27, p57, can inhibit all CDKs