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Medicine

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Kidney

Question
6 out of 17
 

Which of the following is indicative of renal tubular disease (AIIMS May 01, AIIMS Nov 10)



A Hyaline casts
B Coarse granular casts

C Cystine Oxalate cells
D White cell casts

Ans. D White cell casts

Urinary Casts (Ref. H-18th Edi, P- 339)

Casts are formed from Tomm – Horsfall glycoprotein Q, which is synthesized and secreted in the ascending limb of the loop of Henle Q. The Tomm– Horsfall protein along with cellular elements forms the cast in acid medium.

1 Physiologic casts

A. Hyaline casts Q are transparent and cylindrical, and are seen in the urine of normal subjects.

B. Granular casts not specific Qare semitransparent cylinders with refractile granules of uncertain origin.

2 Pathological casts: Casts may contain cellular material (erythrocytes, leukocytes, tubular cells, bacteria of fungi), fibrin, lipids, bile and/or crystals.

Significance of specific urinary casts

Type Significance

1. Red cell casts Glomerulonephritis Q

2. White cell casts Pyelonephritis Q, interstitial nephritis (indicative of infection or inflammation)

3. Broad, waxy cast Chronic renal failure Q

4. Muddy Brown ARF

Kidney Flashcard List

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