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Medicine

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Hematology

Question
6 out of 8
 

Which of the following is not a marker of mantle cell lymphoma?



A CD5
B CD19

C CD23
D CD79B

Ans. C

CD23

Mantle cell lymphoma

1. Age: Middle – Elderly

2. Cells +ve for PAN B marker CD19, CD2, CD22, CD24, CD5,

3. Cell –ve for CD23, CD10,

4. Ig: Increased are IgM, IgD

5. Translocated: t (11:14) it lead to increased expression of cyclidin D1, (Cyclidin D1 +ve)

Co expression of B cell lineage marker CD19 + T cell marker CD5 in CLL & mantle cell.

CD5

CD19

CD23

CD79b

Cyclin D

FM7

Mantle cell

++

++

-

++

++

++

CLL

++

++

++

-

-

-

Ki-67 is an indicator of how fast cells mature and is expressed in a range from about 10% to 90%. The lower the percentage, the lower the speed of maturity, and the more indolent the disease

Hematology Flashcard List

8 flashcards
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