Which of the following is false regarding digoxin?
|A||Dose is reduced in renal failure|
|B||Decreased heart rate|
|C||Increased contractility of cardiac muscles|
|D||Dose is reduced in liver failure|
a. Cardiac glycosides are drugs having cardiac inotropic property. They increase myocardial contractility and output in a hypodynamic heart without a proportionate increase in oxygen consumption.
b. The heart rate is decreased by digitalis and this is more marked in patients of CHF. Digoxin is primarily excreted unchanged by kidney, mainly by glomerular filtration; rate of excretion is altered parallel to creatinine clearance.
c. Its half-life is prolonged in elderly patients and in those with renal insufficiency; dose has to be reduced.