66 out of 86
Which of the following is cell cycle specific
Ans. C Vinblastine
- Vinblastine is a M phase specific Vinca alkaloid and is a rapidly acting drug (BG Katzung’ 10th Edition, pp-891). It blocks the mitotic spindles and produces metaphase arrest.
- Since it produces an interference with chromosomal segregation it is useful in tumors that are rapidly dividing. The drug is used in blood and reproductive cancers.
- Side effects include nausea, vomiting, myelosupression and bone marrow depression. It is given with prednisolone for treatment of lymphomA. Risk of side effect with vinorelbine are intermediate between vincristine and vinblastine, the other two alkaloids used