Which of the following is not effective in Rx of Hot flushes? (AIPG 2011)
Gabapentine, Peroxetine and Venalafaxine are thought to be effective in Rx hot flushes.
1. Raloxifene (selective estrogen receptor modular; SERM) is used to treat & prevent osteoporosis & it’s anti-estrogenic effect on breast & endometrium protects against breast cancer. It does not improve menopausal flushing. Soya beans contain isoflavone (genistein & daidzein), which is strongly estrogenic is also useful in menopausal syndrome.
2. Genistein & teripatide are newer Estrogens under trial.
3. Tamoxifen has anti-estrogenic action on mammary tissue, which acts by upregulating TGF & hence plays ant-icancer action & anti-osteoporotic action. Infact, Tamoxifen can cause hot flushes.
4. Tibolone is used in treatment of post-menopausal symptoms & prevention of osteoporosis. It has estrogenic, progestogenic & weak androgenic action. Apart from its use in terticular failure, hypopitntarism, Ca breast & hereditary angioneurotic edema, androgen in small amount is often added to HRT for treatment of menopausal syndrome.
5. Biphosphonates (etidronate, aldronate) inhibit osteoclast.