79 out of 93
Which of the following is used in osteoporosis for decreasing bone resorption and increasing bone formation. (AIIMS Nov 2011)
Ans. C Strontium
- Bisphosphonates are pyrophosphate compounds and are the drugs used to build bone mass. These act by reducing the resorption while stimulating the osteoblasts.
- Teripartide is 1-34 of amino acid sequence of parathormone prepared by recombinant technology. The drug stimulates new bone formation leading to increase in new bone formation.
- Strontium is a radiopharmaceutical agent that is used for bone pain secondary to metastatic metastasis. However, calcitonin is the drugs of choice for bone pain of metastasis type (Ref: Dhikav V, Drugs of choice’ 3rdEdition’ AITBS Publishers).
- Calcitonin is a hormone having 32 amino acid and is secreted by parafolicular C-cells of thyroid glands. Calcitonin receptor is a G-protein coupled receptor and the drug is used for bone pain and Paget’s disease. It is a calciuric hormone and plays an important role in regulation of calcium levels.