Which of the following is the representative bisphosphonate (alendronate) main mechanism of action? (AIIMS Nov 12)
|A||Activate Vitamin D|
|B||Directly form hydroxyapatite crystals in the bone|
|C||Provide supplemental calcium in the diet|
|D||Reduce the number and activity of osteoclasts in bone|
a. Whether used for osteoporosis (prevention or management, men or women, idiopathic or drug-induced) or Paget’s disease of the bone, bisphosphonates exert their effects on osteoclasts and osteoblasts. The drug is incorporated into bone.
b. When drug-containing bone is resorbed by the osteoclasts, osteoclast function (and, so, subsequent bone resorption) is inhibited. The bisphosphonates also recruit osteoblasts, which then produce a substance that further inhibits osteoclast activity