Which of the following is used in osteoporosis for decreasing bone resorption and increasing bone formation. (AIPG 2010)
Bisphosphonates are pyrophosphate compounds and are the drugs used to build bone mass. These act by reducing the resorption while stimulating the osteoblasts.
a. Teripartide is 1-34 of amino acid sequence of parathormone prepared by recombinant technology. The drug stimulates new bone formation leading to increase in new bone formation.
b. Strontium is a radiopharmaceutical agent that is used for bone pain secondary to metastatic metastasis. However, calcitonin is the drugs of choice for bone pain of metastasis type.
c. Calcitonin is a hormone having 32 amino acid and is secreted by parafolicular C-cells of thyroid glands. Calcitonin receptor is a G-protein coupled receptor and the drug is used for bone pain and Paget’s disease. It is a calciuric hormone and plays an important role in regulation of calcium levels.