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Medicine

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Liver & GIT

Question
10 out of 10
 

Which of the following is true about Reye syndrome?



A More common in children

B Can be caused by aspirin

C Hypoglycemia can occur

D All of the above

Ans. D All of the above

Reye syndrome (Fatty liver with encephalopathy) (Ref. CMDT, 49th ed., Pg. 1270):

1. It is a rare and severe complication of influenza (usually B type) and other viral diseases (eg, varicella), particularly in young children.

2. It consists of rapidly progressive hepatic failure and encephalopathy, and there is a 30% fatality rate.

3. The pathogenesis is unknown, but the syndrome is associated with aspirin use in a variety of viral infections.

4. Hypoglycemia, elevation of serum aminotransferases and blood ammonia, prolonged prothrombin time, and change in mental status all occur within 2–3 weeks after onset of the viral infection.

5. Histologically, the periphery of liver lobules shows striking fatty infiltration and glycogen depletion.

6. Treatment is supportive and directed toward the management of cerebral edema.

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