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Paediatric

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Genetic Disorders

Question
10 out of 49
 

Which of the following is the most likely inheritance pattern in the pedigree given below - (AIPG 2010)



A Autosomal dominant
B Mitochondrial

C Autosomal recessive
D X-linked dominant

Ans. D

X linked dominant

o It is an X linked dominant patten of inheritance.

o The features which suggests the X-linked dominant pattern of inheritance are-

• A single abnormal X chromosome is sufficient to express the disease.

• All of the female offsprings of a diseased male XY will receive the abnormal X chromosome and express the disease, whereas none of the male offspring to the diseased father will have the disease (as sons don't receive X chromosome from their father).

• A diseased mother can transmit the abnormal X chromosome to both daughter and sons equally.

Genetic Disorders Flashcard List

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