Which of the following are Histological features of osteosarcoma? (AIIMS Nov 2009)
|B||Large stromal cells resembling osteoblasts with malignant characteristics like anisocytosis, nuclear pyknosis, pleomorphism|
|C||Direct formation of tumor osteoid and bone by the malignant connective tissue|
|D||All of the above|
All of the above
a. Although the histological features are variable, the absolute criteria for diagnosis are sarcomatous stroma and direct formation of tumor osteiod and bone by the malignant connective tissue therefore the tumor must always contain directly formed neoplastic osteoblastic areas to qualify as an osteogenic sarcoma.
b. The tumor also contains malignant cartilage and fibrous tissue in variable amounts.
c. The latter may dominate the histological picture and a chondrosarcoma or a fibrosarcoma or a fibrosarcoma is suggested but the finding of minute foci of neoplastic osteoid and bone directly formed from the anaplastic cellular stroma categorizes the tumor as osteosarcoma