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2 out of 2

Which of the following substances is likely to be elevated in urine of a carcinoid syndrome patient? (LQ)

A 5-hydroxyindoleacetic acid (5-HIAA)

B Aminolevulinic acid (ALA)

C N-formiminoglutamate (FIGLU)

D Normetanephrine

Ans. A 5-hydroxyindoleacetic acid (5-HIAA)

a. The patient has carcinoid syndrome, which include flushing, diarrhea, and bronchoconstriction.

b. The syndrome results from elaboration of serotonin (5-hydroxytryptamine) by a primary carcinoid tumor in the lungs or ovary or from hepatic metastases from a primary carcinoid tumor in the gastrointestinal tract.