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Pharmacology

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Respiratory Systems

Question
2 out of 47
 

Which of the following acts as a leukotriene receptor antoagonist? (AIIMS May 2011)



A Zafirlukast
B Zileuton

C Cromolyn sodium
D Deriphylline

Ans. A Zafirlukast

The lukasts (Zafirlukast/Montelukast) competitively antagonize cys LT1 (Leukotriene 1) receptor mediated broncho­constriction, vascular permeability and recruitment of eosinophilis.

a. Used for mild to moderate asthma

b. May permit in steroid dose

c. S /E - few cases of churg - strauss syndrome (vas­culitis with eosinophilia). have been reported

d. Headache, rashes, neuropathy

e. 5-LOX (5 Lipo-oxygenase) inhibitor: Zileuton

f. Short duration of action and hepatotoxic potential limit it's use.

Respiratory Systems Flashcard List

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