Which of the following acts as a leukotriene receptor antoagonist? (AIIMS May 2011)
The lukasts (Zafirlukast/Montelukast) competitively antagonize cys LT1 (Leukotriene 1) receptor mediated bronchoconstriction, ↑ vascular permeability and recruitment of eosinophilis.
a. Used for mild to moderate asthma
b. May permit ↓ in steroid dose
c. S /E - few cases of churg - strauss syndrome (vasculitis with eosinophilia). have been reported
d. Headache, rashes, neuropathy
e. 5-LOX (5 Lipo-oxygenase) inhibitor: Zileuton
f. Short duration of action and hepatotoxic potential limit it's use.