Which of the following would most likely be associated with Type A chronic gastritis resulting from autoimmune destruction of parietal cells? (AIIMS Nov 2013)
|A||Decreased growth of luminal bacteria|
|B||Decreased likelihood of developing gastric carcinoma|
|C||Decreased plasma concentration of gastrin|
|D||Increased production of macrocytic red blood cells|
a. Autoimmune destruction of parietal cells would lead to decreased secretion of gastric acid and intrinsic factor.
b. The diminished availability of intrinsic factor would result in poor absorption of dietary vitamin B12.
c. Over time, the vitamin B12 deficiency could lead to pernicious anaemia, which is characterized by increased production of macrocytes (megaloblasts) by the bone marrow.