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Medicine

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Respiratory

Question
14 out of 20
 

Which of the following drug in not given in TBM? (AIIMS Nov 2011)



A INH
B Rifampicin

C Pyrazinamide
D Streptomycin

Ans. D

Streptomycin

Important Points

1). Drugs acting in acid medium – Pyrazinamide (Intracellular org)

2). Drugs acting in Alkaline medium – Streptomycin (Extracellular org)

3). Drugs acting in both medium – INH, Rifampicin

4). Drugs acting on persisters – Rifampicin

5). Drugs crossing blood brain barrier – INH, Rifampicin, pyrazinamide

Extra Edge: Streptomycin does not cross BBB so it is not given in TBM

Extra Edge - Management

First line –

Drugs

Side effects

1). INH

Hepatitis, B6 deficiency, Neuropathy, psychosis, agranulocytosis

2). Rifampicin

Hepatitis, orange urine, flu like syndrome, inactivates oral contraceptives, thrombocytopenia.

3). Ethambutol

Optic neuritis, colour blindness

4). Pyrazinamide

Hepatitis, arthralgias, hyperuricemia

Respiratory Flashcard List

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