Which of the following pharmacokinetic values most reliably reflects the total amount of drug reaching the target tissue after oral administration? (LQ)
|A||Peak blood concentration|
|B||Time-to-peak blood concentration|
|C||Product of the Vd and the first-order rate constant|
|D||Area under the blood concentration –time curve (AUC).|
a. The fraction of a drug dose absorbed after oral administration is affected by the variety of factors that can strongly influence the peak blood levels and the time-to-peak blood concentration.
b. The Vd and the total body clearance (Vd∞ first-order κe) also are important in determining the amount of drug that reaches the target tissue. Only the area under the blood concentration-time curve, however, reflects absorption, distribution, metabolism, and excretion factors; it is the most reliable and popular method of evaluating bioavailability.