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Pharmacology

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CNS Part- 2

Question
20 out of 42
 

Which of the following drugs has a high affinity for 5-HT2 receptors in the brain, does not cause

extrapyramidal dysfunction or hematotoxicity, and is reported to increase the risk of significant QT prolongation



A Chlorpromazine
B Clozapine

C Olanzapine
D Ziprasidone

Ans. D Ziprasidone
  1. +Clozapine, olanzapine and ziprasidone are atypical antipsychotic agents that act by blocking 5HT2 receptors.
  2. Chlorpromazine is a typical antipsychotic drug. It blocks D2 receptors in the brain and can cause extrapyramidal symptoms.
  3. Major adverse effect of clozapine is agranulocytosis (hematotoxic) and seizures.
  4. Olanzapine causes weight gain.
  5. Ziprasidone can cause QT prolongation leading to torsades de pointes.

CNS Part- 2 Flashcard List

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