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Physiology

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Endocrinology

Question
3 out of 10
 

Which of the following decreases insulin release? (AIPG 2010)



A Gastrin
B Epinephrine

C Secretin
D Growth Hormone

Ans. B Epinephrine
  1. Factors affecting insulin secretion)

STIMULATORS

INHIBITORS

Glucose

Somatostatin

Mannose

2-Deoxyglucose

Amino acids (leucine, arginine, others)

Mannoheptulose

Intestinal hormones (GIP, GLP-1, gastrin, secretin, CCK)

α-Adrenergic stimulators (Adr, NE)

β-Keto acids

β-Adrenergic blockers

Acetylcholine

Diazoxide

Glucagon & Growth Hormone

Thiazide diuretics

Cyclic AMP and various cyclic AMP-generating substances

K+ depletion

β-Adrenergic stimulators

Phenytoin

Theophylline

Insulin

Sulfonylureas

Microtubule inhibitors

Note: main action of Epinephrine is decrease in insulin release

  1. Mechanism of insulin release

a. Glucose enters β cells via GLUT 2 transporters, which is metabolized to produce ATP.

b. Increased ATP inhibits ATP sensitive K+ channels, resulting in ↓ K+ efflux which depolarizes the β cells.

c. This opens voltage-sensitive Ca2+ channels. The Ca2+ influx causes insulin release by exocytosis.