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Dermatology

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Nevus

Question
3 out of 28
 

Which of the following statement about mycosis fungoides is not true?



A It is the most common form of cutaneous lymphoma.

B Pautrier's micro abscesses are seen.

C It has an indolent course and is easily amen able to treatment

D It is a/w erythroderma and peripheral leuke­mia

Ans. C

It has an indolent course and is easily amen able to treatment

1). Skin is the 2nd most common site of extranodal lymphoma next only to GIT.

2). T cell lymphoma are the most common type of cutaneous lymphoma consist of around 65% of all lymphomas arising from skin.

3). Mycosis fungoides is also called as cutaneous T cell lymphoma commonly seen in middle aged male.

Clinical Features

1). It usually present with slow growing localized or generalized erythematous patches over trunk, usually pruritic for around a decade before becoming significant. Mostly are of more than 5cm in diameter.

2). In advanced cases. Lymphadenopathy may occur.

3). Patch stage Plaque stage Nodular / Tumour stage

Histology

1). The classical finding is the formation of micro abscesses in the epidermis known as Pautrier’s micro abscesses.

2). A particular syndrome in patient with this lymphoma presents with erythroderma, lymphadenopathy and circulating tumor cells in peripheral blood this is known as Sézary syndrome.

Treatment

1). It is a slow growing tumour with an indolent course and has a good prognosis if diagnosed early in the disease.

2). Patch stage – Topical corticosteroid and PUVA

3). Plaque stage – Electron beam therapy

4). Tumour stage – Radiotherapy / Chemotherapy

5). Prognosis is worst when.

a. Tumors are present

b. There is lymphadenopathy

c. > 10% of skin surface is involved.

d. There is generalized erythroderma

6). So/ though it has an indolent course, it is not easily amenable to treatment.

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