Which of the following statements about pancreatic carcinoma is not true
|A||Mutation in P53 gene is associated in 75% of cases|
|B||Hereditary pancreatitis significantly increases the risk|
|C||Median survival in locally advanced (Stage III) disease is 3-6 months|
|D||Five year survival after curative pancreaticoduo-denectomy is 15 – 20 %|
Pancreatic cancer genetics (K- ras: 100%, p16- 86%, p53-76%, DPC4- 53% and BRCA2-10%)
HNPCC, Familial breast cancer (BRCA2), Peutz Jegher, Ataxia Telengectasia, Familial atypical multiple mole melanoma syndrome (FAMMM) and hereditary pancreatitis are six genetic syndrome associated with pancreatic cancer
The reported 5-year survival following resection of a pancreatic adenocarcinoma ranges from 7% to 25%. The median survival is 11-20 months.