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Pathology

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Inflammation

Question
5 out of 14
 

Which of the following substances is produced by the action of lipoxygenase on arachidonic acid, is a potent chemotactic factor for neutrophils, and causes aggregation and adhesion of leukocytes? (AIIMS May 2013)



A C5a
B Prostacyclin

C IL-8
D Leukotriene B4

Ans. D Leukotriene B4

a. Leukotriene B4 is a potent chemotactic agent that also causes aggregation and adhesion of leukocytes.

b. Additionally, leukotrienes C4, D4, and E4 cause increased vascular permeability, bronchoconstriction, and vasoconstriction. Other chemotactic factors for neutrophils include C5a and IL-8, but these substances are not formed from AA.

Inflammation Flashcard List

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