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Medicine

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Liver & GIT

Question
5 out of 10
 

Which of the following hepatitis viruses have significant perinatal transmission: (AI 2003)



A Hepatitis E virus
B Hepatitis C virus

C Hepatitis B virus
D Hepatitis A virus

Ans. C Hepatitis B virus

Extra Edge: Acute Hepatitis


1. Focal/ Centrifugal Necrosis

2. Ballooning Degeneration

3. Acidophilic Degeneration of hepatocyte (councilman bodies)

4. Architecture Changes

Table 298-2 Clinical and Epidemiologic Features of Viral Hepatitis (Ref: Hari-18th ed., pg. 2546, Table 304.2)

Feature

HAV

HBV

HCV

HDV

HEV

Incubation (days)

15–45, mean 30

30–180, mean 60–90

15–160, mean 50

30–180, mean 60–90

14–60, mean 40

1. Onset

Acute

Insidious or acute

Insidious

Insidious or acute

Acute

2. Age preference

Children, young adults

Young adults (sexual and percutaneous), babies, toddlers

Any age, but more common in adults

Any age (similar to HBV)

Young adults (20–40 years)

3. Transmission

4. a. Fecal-oral

+++

+++

b. Percutaneous

Unusual

+++

+++

+++

c. Perinatal

+++

±

+

d. Sexual

±

++

±

++


5. Clinical

a. Severity

Mild

Occasionally severe

Moderate

Occasionally severe

Mild

b. Fulminant

0.1%

0.1–1%

0.1%

5–20%

1–2%

c. Progression to

chronicity

None

Occasional (1–10%) (90% of neonates)

Common (85%)

Common

None

6. Carrier

None

0.1–30%

1.5–3.2%

Variable

None

7. Cancer

None

+ (neonatal infection)

+

±

None

8. Prognosis

Excellent

Worse with age, debility

Moderate

Acute, good

Chronic, poor

Good

9. Prophylaxis

IG

Inactivated vaccine

HBIG

Recombinant vaccine

None

HBV vaccine (none for HBV carriers)

Vaccine

10. Therapy

None

Interferon

Lamivudine

Adefovir

Pegylated interferon

Entecavir

Telbivudine

Pegylated interferon plus ribavirin

Interferon ±

None

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