Medical and Surgical Complications in Pregnancy
Which of the following congenital infections lead to maximum CNS damage in the fetus? (AIPG 2008)
|A||Rubella and CMV|
|B||Rubella and toxoplasmosis|
|C||CMV and toxoplasmosis|
|D||HIV and CMV|
CMV and toxoplasmosis
1. Toxoplasmosis produces the most severe damage to CNS and the prognosis is very poor. Transplacental Infection with toxoplasma (a protozoon) results in damage to brain, eyes, skeletal and cardiac muscles, liver and lungs.
2. Intrauterine CMV infection results in microcephaly, cerebral calcification, sensorineural deafness, psychomotor retardation, etC.
3. This damage is more serious than the manifestations of rubella infection. Fetal infection with Rubella can result in cerebral palsy, microcephaly, mental retardation, microphthalmia etc.
4. HIV infection does not produce any significant CNS damage comparable to the aforementioned infections.