Which of the following statement(s) is/are true concerning soft tissue repair? (AIIMS Nov 2012)
|A||The first stage involves a formation of granulation tissue|
|B||The initial pattern of collagen fibers and the degrees of waviness is random and therefore not as functional as the normal structure|
|C||Early immobilization, regulated physical stimuli, and good vascular supply are beneficial to healing|
|D||Normal physiologic loading conditions impair wound remodeling|
a. The healing of soft tissue occurs in stages. The first stage involves a granulation tissue, in which the collagen fibers are oriented in a random pattern and the degree of waviness is likewise random.
b. This tissue is not as functional as the more optimal normal structure. In time, the soft tissue is remodeled to produce an architecture more nearly that of normal intact tissue.
c. Factors associated with beneficial effects on healing include early immobilization, regulated physical stimuli, and good vascular supply.
d. Remodeling or adaptation of soft tissues has also been shown to occur under normal physiologic loading conditions.
e. There are reports of training effects increasing the properties of tissues and metabolically active cells incorporated within the matrix.