General Virology and DNA Viruses
Which of the following statements regarding the serologic diagnosis of infectious mononucleosis is correct?
|A||A heterophile antibody is formed that reacts with the membrane protein of EBV.|
|B||A heterophile antibody is formed that agglutinates sheep or horse red blood cells.|
|C||A heterophile antigen occurs that cross-reacts with atypical lymphocytes.|
|D||A heterophile antigen occurs following infection with both EBV and CMV.|
a. A nonspecific heterophile agglutination test (Paul Bunnel / Monospot test) can be used to diagnose EBV infectious mononucleosis within a week to months of infection.
b. It is characterized by formation of heterophile antibodies against sheep or horse RBC’s. Infectious mononucleosis-like infection caused by CMV is heterophile negative.