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Pharmacology

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General Pharmacology

Question
49 out of 91
 

Which of the following property of drug will enable it to be used in low concentrations:



A High affinity
B High specificity

C Low specificity
D High stability

Ans. A High affinity

Affinity is the ability of the drug to bind with the receptor and is determined by the interaction of the molecular structures of the receptor and the drug.

Affinity

a.The receptor occupancy by the drug is needed to elicit a response, so drug with hyper affinity will occupy larger number of receptor and produce more response at a given concentration than drug with lower affinity.
b.Affinity relates the drug concentration to the functional receptor occupancy.
c.The drug which has more affinity will occupy more receptor at a given concentration and the drug which has low affinity will occupy lower number of receptor at a given concentration.

Efficacy (Intrinsic activity)

a. It is the ability of the drug to activate (induce a conformational change in) the receptor consequent to receptor occupation.

b. The two properties of affinity and intrinsic activity (IA. are independently variable, i.e. drugs with the same affinity can possess different degrees of intrinsic activity.

General Pharmacology Flashcard List

91 flashcards
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