Which of the following statements about Diazoxide is false? (AIIMS May 2011)
|A||It acts by causing prolonged opening of ATP depended K+ channels in beta cells|
|B||It can cause severe hypoglycemia.|
|C||It can be used to treat patients with insulinoma.|
|D||It is used as an antihypertensive agent.|
· Diazoxide cause hyperglycemia and not hypoglycemia
· Diazoxide is an effective and relatively long-acting parenterally administered arteriolar dilator that is occasionally used to treat hypertensive emergencies.
· It acts by opening ATP sensitive potassium channels.
· The most significant toxicity from diazoxide has been excessive hypotension.
· Diazoxide inhibits insulin release from the pancreas (probably by opening potassium channels in the cell membrane) and is used to treat hypoglycemia secondary to insulinoma.
· Occasionally, hyperglycemia complicates diazoxide use, particularly in persons with renal insufficiency.