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Pathology

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The Endocrine System

Question
6 out of 32
 

Which of the following gene defect is associated with development of medullary carcinoma of thyroid? (LQ)



A RET proto oncogene
B Fap gene

C Rb gene
D BRCA 1 gene

Ans. A i.e., RET proto oncogene Ref -Robbin's 8thed. p. 1124]

Thyroid carcinoma

a. The major types of carcinoma and their relative frequency ;-

b. Papillary cacinoma→75% to 85% (most common) → Medullary carcinoma →5%

Most thyroid carcinomas are derived from the follicular epithelium, except for medullary carcinoma which is derived from the Follicular carcinoma → 10% to 2% Anaplastic carcinoma →<5%

c. parafallicular or 'C' cells.

d. Genetic factors in different thyroid carcinoma

i. Papillary → o Tyrosine kinase receptors RET or NTRK 1

o RAS mutation

o BRAF oncogene

ii. Follicular o RAS oncogene (NRAS, HRAS and KRAS)

o PAX8- PPARr1 translocation

iii. Medullary → o RET protooncogene.

iv. Familial medullary cancers account for most inherited cases of thyroid cancer.

v. Familial nonmedullary thyroid cancers (papillary and follicular) are very rare.

The Endocrine System Flashcard List

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